After struggling through depression during medical school, Dr. Joseph Tafur was introduced to peyote by a friend who was researching psychedelics as a medical intervention. He reports that he quickly realized the connection between modern medical interventions, such as anti-depressants and psychedelics. In 2007 Dr. Tafur traveled to the Amazon and began his exploration of Ayahuasca and later began his training in Shipibo shamanism. Dr. Tafur’s medical background and his training as a Shipibo shaman position him to articulately explain the Western understanding of this spiritually-based approach to healing. Dr. Tafur’s book is full of case studies, and his use of these examples provide a first-hand account of what many know to be true: that many individuals do not feel adequately understood by the traditional western medicine. We discuss epigenetics, specifically how researchers are beginning to understand how trauma can be passed down from one generation to the other. We frame depression and other psychological issues as a disorder of the imagination, wherein the individual is cut off from their sense of creativity, and which cuts the individual off from imagining other possibilities in their life, and therefore they suffer under the burden of the discomfort and belief that change is not possible. Although Dr. Tafur can use modern medical language, he prefers to speak about love and broke-heartedness as it relates to what is missing in modern medicine.