We begin this conversation acknowledging the dynamic between biological reductionism and mystical experience within the ever-growing field of psychedelic assisted therapies. The conversation continues by exploring consciousness, spirituality, the nature of religion, the expanding field of end of life care and psychedelics, mystical experience, the history of psychedelics as a healing modality, integration of mystical experience, Aldous Huxley’s influence, death as a spiritual process, the medicalization of healthcare, we discuss Tony’s recent chapter, Utility of psychedelics in the treatment of psycho-spiritual and existential distress in palliative care: A Promising new paradigm, the research history of psychedelics, constructivism and perennialism, legalization of psychedelics, and addressing the concern for the medicalization of psychedelics.