Dr. Price interviews Dr. Mark Plotkin, one of the world’s renowned ethnobotanists who has studied traditional indigenous plant use with elder shamans (traditional healers) of Central and South America for much of the past 30 years. In this conversation we explore traditional Amazonian medicine, the great ethnobotanist Dr. Richard Schultes, shamanism, the modern psychedelic renaissance, the ethics of entheogens, ethnobotany 101, Western and Indigenous medicine and spiritualty, the placebo effect, culture, Covid, building relationships with the indigenous community in the Amazon, conservation and the Amazon, Western prohibition on alternate states of consciousness, a brief history of substances and alternate states, and many other practices that the world may gain by studying those who have learned to live with the earth, not dominating it.