This conversation begins with a discussion of the banisteriopsis vine (ayahuasca) featured in the background. We explore Dr. McKenna’s first adventure down to South America to study and explore psychedelics used in the Amazonian medico-religious process. This endeavor would eventually connect him with several elder medicine men who created mixtures for Dennis to study – “We want to learn everything that you know about ayahuasca.” We discuss how the indigenous folks of the Amazon responded to the scientists who sought to investigate their sacramental plant, the rubber boom of the early 20th century, lost aspects of the Amazonian ethnomedical tradition, the hard problem of consciousness, the limitations of reductionism, the value of science, limitations of science, an overview of the journey to La Chorrera, building the temple for “spiritual” experience, or ecstatic/mystical experience, the body as apothecary, theories of consciousness, the molecule and the “trip,” scientific bias of the west, the Default Mode Network, the value of psychedelics to the scientific community, and the McKenna Academy.Bio:Dennis McKenna is an American ethnopharmacologist, research pharmacognosist, lecturer and author. He is a founding board member and the director of ethnopharmacology at the Heffter Research Institute, a non-profit organization concerned with the investigation of the potential therapeutic uses of psychedelic medicines. Dennis also serves on the Advisory Board of the American Botanical Council; as Founder and Executive Director for the Institute for Natural Products Research; as an Independent Research Consultant to the Phytomedicine and Nutraceutical Industry; was formerly on the Editorial Board of Phytomedicine, International Journal of Phytotherapy and Phytopharmacology; and is an adjunct professor in the Center for Spirituality and Healing at the University of Minnesota. In that role, he has taught graduate courses in Botanical Medicines and Ethnopharmacology and an inter-session ‘intensive’ in Hawaii each January called Plants in Human Affairs. He has also taught summer field courses in Ecuador for the University of Arizona, and courses in the Amazon and Andes for Pharmacy doctoral students at the University of Kansas and the Albany College of Pharmacy and Health Sciences. Dr. McKenna received his Master’s Degree in Botany from the University of Hawaii in 1979, his Ph.D. in Botanical Sciences from the University of British Columbia in 1984, and continued into post-doctoral research fellowships in the Laboratory of Clinical Pharmacology, National Institute of Mental Health (NIMH), and in the Department of Neurology, Stanford University School of Medicine. His research has included the pharmacology, botany, and chemistry of ayahuasca and oo-koo-hé. He has also conducted extensive ethnobotanical fieldwork in the Peruvian, Colombian, and Brazilian Amazon.Since 2019, he has been working with colleagues to manifest a long-term dream: the McKenna Academy of Natural Philosophy, a non-profit organization founded in the spirit of the ancient Mystery Schools and dedicated to the study of plant medicines, consciousness, intelligence in nature, preservation of indigenous knowledge and a re-visioning of humanity's relationship with Nature. Dr. McKenna is author or co-author of 6 books and over 50 scientific papers in peer-reviewed journals.