Mary shares her personal encounters with suffering, particularly as a professional in her scientific network and system. She highlights the constraints and limitations inherent within her field's foundational principles, which often hinder expansive thinking and inspiration. Mary also talks about her journey joining the Johns Hopkins Center for Psychedelic and Consciousness Research, shedding light on what prepared her for becoming a part of this vibrant community. We further examine the foundation of the psilocybin therapy process at Hopkins. Mary emphasizes the importance of setting genuine intentions when individuals choose psychedelics as part of their healing journey. Hopkins has been at the forefront of psychedelic therapies, collaborating closely with the FDA to explore the efficacy of these natural compounds in contexts such as palliative care, treatment-resistant depression, eating disorders, and trauma healing. In this illuminating dialogue, Mary discloses the remarkable benefits of psilocybin interventions, including a notable depression study where subjects witnessed a 50% reduction in treatment-resistant depression symptoms. Our conversation broadens to encompass themes of love, safety, fear, laughter, play, and joy as potent forces for healing and transformation. We conclude with thought-provoking insights into forgiveness and death, rounding off a deeply profound exploration of human suffering and healing.